Here are a couple to get you going...
"Hey, William Shatner was right. We should get a life!"

[to the barman] "Jim Beam me up, Scotty!"

"Guys, what are we doing here? There's a strip joint down the road!"

"You want HOW MUCH for that tacky looking uniform/prop/piece of old memorabilia???"

"You're Grand-Mother is the Grand Nagus, and your mother dresses you funny !!"

Or

"You have one-mother-of-a zit on your forehead!!!"

or

"Is that a dagger under your belt, or are you just happy to see me!?"

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-There can be only Nine !! ..mmm.. maybe 10 !!

- Alshrim Dax
The Other Dax:

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I bet when Neanderthal kids would make a snowman, someone would
always end up saying "Don't forget the big heavy eyebrows." Then they would all get embarrassed because they remembered they had the big hunky eyebrows too, and then they would get mad and eat the snowman.

-Jack Handey

"Who's that American person on the stage?"

"My whole family loves it. In fact, everyone I know does!"

"Harve Bennett had a great idea for ST:VI!"

"I'd like you to meet my girlfriend here.."

"Well, football is my first love"

"I don't own a VCR"

"DAMN! That's a sharp uniform you got there my friend!"

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"You don't need eyes to see; you need VISION"
- Faithless / Reverence

Rabid fans procede to beat the shit out of him.

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I am not responsible for the stupidity of other people.

Rebecca Romijn: No, he's too good for you, he's mine!

Me: Ladies, there's enough of this manly captain to go around! Who's up for a little handling of the 'Captain's Log'?

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I bet when Neanderthal kids would make a snowman, someone would
always end up saying "Don't forget the big heavy eyebrows." Then they would all get embarrassed because they remembered they had the big hunky eyebrows too, and then they would get mad and eat the snowman.

-Jack Handey

"Hey, has anyone ever noticed how Captain Kikr always seemed to get the girls?"

"What a wonderful singing voice that Shatner has!"

"I take it that your wife Genie made home dinner for the last 7-8 years Mr. Frake?"

"Oh my God, you gained weight since I saw you in Generations!!"

"So where are the adult toys at?"

"Wait a second, this isn't the NRA Convention..."

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Show me the meaning of being lonely
Is this the feeling, I need to walk in
Tell me why I can't be there where you are
There's something missing in my heart

"I'll let you have that prop tricorder for half the tagged price because it's wildly inaccurate, poorly made, and generally a piece of crap."

"I have thirty more binders of Brent Spiner snapshots just like this one at home. Yes, I am stalking him."

"Wow, those guys in the Starfleet uniforms are in shape. They must work out at the gym a lot."

"You know, I just can't get enough of fans in T-shirts."

"That home-made Klingon head piece is almost the color of your face. Congratulations."

"My name is John Smith. I'm in Starfleet, but I'm not an officer, in Intelligence, Weapons, Starship Design, or The Marines."

"I hope there's a slide show."